The Helmholtz Centre for Environmental Research (UFZ) with its 1,100 employees has gained an excellent reputation as an international competence centre for environmental sciences. We are part of the largest scientific organisation in Germany, the Helmholtz association. Our mission: Our research seeks to find a balance between social development and the long-term protection of our natural resources.
The EU project ERGO (Endocrine Guideline Optimization) has started on 1 January 2019 and covers 16 partners from nine countries including the USA. It aims at improving the hazard and risk assessment of thyroid disrupting compounds (TDCs). A primary goal is to introduce methods for extrapolating TDC effects across vertebrates as well as from fish or amphibian to human. To this end, the project explores and applies thyroid-related biomarkers, apical endpoints, and in particular non-animal in vitro and in silico information. Our focus is the impact of TDCs on the HPT (hypothalamus-pituitary-thyroid) axis, employing an AOP (adverse outcome pathway) framework addressed through an IATA (integrated approach to testing and assessment) scheme.
The UFZ Department of Ecological Chemistry undertakes mechanistic research into molecular toxicology and chemodynamics, and contributes to ERGO through the following major tasks: TDC bioavailability profiling, PBTK (physiologically based toxicokinetics) modelling for rat and fish, in vitro biotransformation in S9 enzyme assays, 3D ligand-receptor binding and QSAR modelling, and across-project database maintenance.
As from now, the following position can be filled:
Doctoral student (m/f/x)
Subject: In silico research into 3D docking/QSAR and PBTK modelling
working time: 65 % (25,35 hours per week)
Continuous application until position is filled.
- Ligand-receptor docking
- Computational chemistry including quantum chemical calculations
- PBTK model building (e.g. Excel VBA) and application
- University Master of Science or Diploma in chemistry or related natural science subjects
- Expertise/interest in the following subject areas:
Molecular modelling of ligand-receptor binding, computational chemistry, and QSARs
- Interest in high-level academic research within an international network
- Appropriate knowledge of English to enable active participation in the international project (our lab uses both German and English)
- Top level interdisciplinary research at a centre with an excellent international reputation
- Reliable supervision as a precondition for independent work
- A supportive and interesting team that is highly integrated in relevant scientific networks
- Support and training courses by our graduate school (HIGRADE)
- Diverse offers for a balance between family and work
- Remuneration in accordance with the TVöD public-sector pay grade 13
Equal opportunities are an integral part of our personnel policy; we therefore particularly welcome applications from qualified women. Severely disabled persons are given priority where applicants are equally qualified.
Your contact for any questions you may have about the job:
Prof. Dr. Gerrit Schüürmann
(Head of Department, email@example.com) or
Dr. Ralph Kühne
Closing date for applications:
Place of work: LeipzigPlease use our online application system for your application.
More information about jobs at the UFZ:www.ufz.de/career
Helmholtz-Zentrum für Umweltforschung GmbH – UFZ
04318 Leipzig, Germany