Postdoctoral Fellow in Life Science

The University of Helsinki is a leading Nordic university with a strong life science research. An international academic community with a critical outlook and a creative attitude is aiming to build a better future together.

Helsinki Institute of Life Science, HiLIFE https://www.helsinki.fi/en/helsinki-institute-of-life-science , is a new life science institute at the University of Helsinki established in 2017 supporting high quality research across campuses and life science faculties. HiLIFE builds on existing strengths, new recruits and partnerships to create an attractive international environment for solving grand challenges in health, food, and environment. It coordinates research infrastructures in life sciences, provides research-based interdisciplinary training and supports researchers within its units and partner faculties. In 2019 HiLIFE has a staff of 600 and budget of 59 M€.

HiLIFE operates mainly in the campuses of Meilahti and Viikki.

Laboratory of Structural Biology at HiLIFE invites applications for a

POST-DOCTORAL POSITION IN MEMBRANE PROTEIN STRUCTURAL BIOLOGY

for a fixed-term of three years.

Prior expertise in membrane protein purification is essential. Prior expertise in cryogenic electron microscopy (cryo-EM) and/or genome editing is desirable but not required. Positions are initially made for three years, with the possibility of renewal, and available immediately.

We offer you a highly collaborative, supportive and international research environment. The working language of the laboratory is English. Our research is aimed at understanding the structure and function of biological macromolecules and their complexes with emerging focus on membrane proteins. We apply a range of methods, including cryo-EM and correlative imaging. We are also active in computational method development for these tasks. In this project the successful candidate will focus on the structure and organisation of Gap junctions by using cryo-EM, single particle analysis and tomography.

The local cryo-EM core facility houses a Talos Arctica with a Falcon III detector and a Volta phase
plate, in addition to a Linkam/Zeiss setup for correlative imaging. Access to several other high-end
microscopes, including a Titan Krios, is available for the project in affiliated facilities. Finnish high performance computing center (CSC) provides CPU and GPU clusters for data processing.

The position is funded by HiLIFE and the Sigrid Juselius Foundation, a Finnish foundation promoting medical research.

Essential skills
• Hold a PhD degree in molecular biology, biochemistry or a related field.
• Publication record in leading peer-reviewed journals.
• Excellent familiarity with the current literature and research questions in the topic of their own research.
• Experience in membrane protein purification.
• Good communication skills, including the ability write research articles and reviews and to present work at international meetings.

Desirable skills
• Experience in cryo-EM data processing, for example single particle analysis, tomography, and/or sub-tomogram averaging.
• Use of CRISPR/Cas9 methods.
• Past role in independently managing a discrete area of a research project.

Applications should include a motivation letter (maximum of 1 page), CV (maximum of 2 pages), contact information of 2 referees (one of which should be the current line manager), and a list of publications. Up to three most important publications should be highlighted and a one paragraph summary of the applicant’s contribution should be provided for each. All documents should be submitted as a single PDF file.

To apply, please submit your application using the University of Helsinki electronic recruitment system by clicking on Apply for job. Internal applicants (i.e., current employees of the University of Helsinki) must submit their applications through the SAP HR portal.

The application deadline is April 29th, 2019. The preferred starting date is September 1st, 2019, at the latest.

For informal enquiries, please contact Associate Professor Juha Huiskonen, juha.huiskonen(at)helsinki.fi. Technical assistance with the University’s electronic recruitment system: recruitment@helsinki.fi.

Due date

29.04.2019 23:59 EEST